Name: ARN-6039
Rating: 5 (10 reviews)

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HIT ID:HIT214318147
Cas No:1675206-11-7
常用名:ARN-6039
别名:ARN6039, ARN 6039
IUPAC:6-methoxy-5-(morpholin-4-yl)-2-{[3-(trifluoromethyl)pyridin-2-yl]methyl}-2,3-dihydro-1H-inden-1-one
IUPAC:6-methoxy-5-(morpholin-4-yl)-2-{[3-(trifluoromethyl)pyridin-2-yl]methyl}-2,3-dihydro-1H-inden-1-one
InChI key:CQSDLVKTQRLMJB-UHFFFAOYSA-N

分子式:C21H21F3N2O3
分子量:406.405
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:COc1cc2C(=O)C(Cc3ncccc3C(F)(F)F)Cc2cc1N1CCOCC1
SMILES:COc1cc2C(=O)C(Cc3ncccc3C(F)(F)F)Cc2cc1N1CCOCC1

ARN-6039 is an orally available inverse agonist of RORγ for Autoimmune Neuroinflammatory Demyelinating Disease. The activity of ARN-6039 against RORγ was demonstrated in a RORγ-activated IL-17A Prom/LUCPorter assay in HEK 293 cells (360 nM) and in IL-17 release from CD4+T cell assays (220 nM).

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