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  3. HIT214318331
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HIT214318331
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HIT214318331
  • HIT ID:HIT214318331
  • Cas No:922717-97-3
  • 常用名:CBR-2092
  • 别名:TNP-2092, TNP2092, TNP 2092, CBR2092
  • IUPAC:8-[(3R)-3-(1-{[1-({[(7S,9Z,11S,12R,13S,14R,15R,16R,17S,18S,19Z,21Z)-13-(acetyloxy)-2,15,17,27,29-pentahydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-6,23-dioxo-8,30-dioxa-24-azatetracyclo[23.3.1.1^{4,7}.0^{5,28}]triaconta-1,3,5(28),9,19,21,25(29),26-octaen-26-yl]methylidene}amino)piperidin-4-yl](methyl)amino}cyclopropyl)pyrrolidin-1-yl]-1-cyclopropyl-7-fluoro-9-methyl-4-oxo-4H-quinolizine-3-carboxylic acid
    IUPAC:8-[(3R)-3-(1-{[1-({[(7S,9Z,11S,12R,13S,14R,15R,16R,17S,18S,19Z,21Z)-13-(acetyloxy)-2,15,17,27,29-pentahydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-6,23-dioxo-8,30-dioxa-24-azatetracyclo[23.3.1.1^{4,7}.0^{5,28}]triaconta-1,3,5(28),9,19,21,25(29),26-octaen-26-yl]methylidene}amino)piperidin-4-yl](methyl)amino}cyclopropyl)pyrrolidin-1-yl]-1-cyclopropyl-7-fluoro-9-methyl-4-oxo-4H-quinolizine-3-carboxylic acid
  • InChI key:OPZFMLLAJBIKAN-NHJRELDKSA-N
  • 分子式:C65H81FN6O15
  • 分子量:1205.388
  • 氢键供体数 (HBD):
  • 氢键受体数 (HBA):
  • LogP:
  • SMILES:CO[C@H]1\C=C/O[C@@]2(C)Oc3c(C2=O)c2c(O)c(C=NN4CCC(CC4)N(C)C4(CC4)[C@@H]4CCN(C4)c4c(F)cn5c(c4C)c(cc(C(O)=O)c5=O)C4CC4)c(NC(=O)\C(C)=C/C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C)c(O)c2c(O)c3C |c:3,66,68|
    SMILES:CO[C@H]1\C=C/O[C@@]2(C)Oc3c(C2=O)c2c(O)c(C=NN4CCC(CC4)N(C)C4(CC4)[C@@H]4CCN(C4)c4c(F)cn5c(c4C)c(cc(C(O)=O)c5=O)C4CC4)c(NC(=O)\C(C)=C/C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C)c(O)c2c(O)c3C |c:3,66,68|
  • CBR-2092 is a DNA-directed RNA polymerase and DNA topoisomerase inhibitor. CBR-2092 exhibited rifampin-like potency as an inhibitor of RNA polymerase, was an equipotent (balanced) inhibitor of DNA gyrase and DNA topoisomerase IV, and retained activity against a prevalent quinolone-resistant variant. Studies of mutant strains that exhibited reduced susceptibility to CBR-2092 further substantiated RNA polymerase as the primary cellular target of CBR-2092, with DNA gyrase and DNA topoisomerase IV being secondary and tertiary targets, respectively, in strains exhibiting preexisting rifampin resistance.
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  • 供应商
    TargetMolSC
    规格
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    ¥ 10,600.00
    1

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