Name: Diazaborine
Rating: 5 (10 reviews)

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HIT ID:HIT214318378
Cas No:22959-81-5
常用名:Diazaborine
别名:Pkf-84474, Pkf 84474, Pkf 84.474, Diazaborine compound 2b18
别名:Pkf-84474, Pkf 84474, Pkf 84.474, Diazaborine compound 2b18
IUPAC:2-(4-methylbenzenesulfonyl)-1,2-dihydro-2,3,1-benzodiazaborinin-1-ol
IUPAC:2-(4-methylbenzenesulfonyl)-1,2-dihydro-2,3,1-benzodiazaborinin-1-ol
InChI key:UQIDNSKBUXCODH-UHFFFAOYSA-N

分子式:C14H13BN2O3S
分子量:300.14
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:Cc1ccc(cc1)S(=O)(=O)N1N=Cc2ccccc2B1O |c:12|
SMILES:Cc1ccc(cc1)S(=O)(=O)N1N=Cc2ccccc2B1O |c:12|

Diazaborine inhibits maturation of rRNAs for the large ribosomal subunit. Diazaborine blocks ribosome biogenesis by inhibiting the AAA-ATPase Drg1. Diazaborine treatment causes, within minutes, a rapid redistribution of the protein from the nucleolus to the periphery of the nucleus, which provides a possible explanation for the effect of diazaborine on rRNA processing.

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