Name: Manzamine A
Rating: 5 (10 reviews)

有库存

sdf 文件

结构编辑

类似物检索

HIT ID:HIT214318542
Cas No:104196-68-1
常用名:Manzamine A
别名:Keramamine A
IUPAC:(1R,2R,4R,12R,13S,16Z,22S)-25-{9H-pyrido[3,4-b]indol-1-yl}-11,22-diazapentacyclo[11.11.2.1^{2,22}.0^{2,12}.0^{4,11}]heptacosa-5,16,25-trien-13-ol
IUPAC:(1R,2R,4R,12R,13S,16Z,22S)-25-{9H-pyrido[3,4-b]indol-1-yl}-11,22-diazapentacyclo[11.11.2.1^{2,22}.0^{2,12}.0^{4,11}]heptacosa-5,16,25-trien-13-ol
InChI key:FUCSLKWLLSEMDQ-MGOZPMTQSA-N

分子式:C36H44N4O
分子量:548.775
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:[H][C@]12C[C@]34C[N@@]5CC[C@@]3([H])C(=C[C@@](O)(CC\C=C/CCCC5)[C@]4([H])N1CCCCC=C2)c1nccc2c3ccccc3[nH]c12 |w:29.32,c:11,17|
SMILES:[H][C@]12C[C@]34C[N@@]5CC[C@@]3([H])C(=C[C@@](O)(CC\C=C/CCCC5)[C@]4([H])N1CCCCC=C2)c1nccc2c3ccccc3[nH]c12 |w:29.32,c:11,17|

Manzamine A is a GSK-3 inhibitor and vacuolar ATPase uncoupler found in marine sponges. It inhibits autophagy and tumor growth in cancer models, suppresses foam cell formation in macrophages, prevents growth of gram negative and gram positive bacteria, and decreases tau hyperphosphorylation.

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