Name: Org-6906
Rating: 5 (10 reviews)

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sdf 文件

结构编辑

类似物检索

HIT ID:HIT214318591
Cas No:67384-25-2
常用名:Org-6906
别名:Org-6906 free, Org6906, Org 6906
IUPAC:(1S,9S,10S)-tricyclo[7.3.1.0^{2,7}]trideca-2(7),3,5,11-tetraen-10-amine hydrochloride
IUPAC:(1S,9S,10S)-tricyclo[7.3.1.0^{2,7}]trideca-2(7),3,5,11-tetraen-10-amine hydrochloride
InChI key:FTKXWCQSVJPWPZ-FCMXFIQISA-N

分子式:C13H16ClN
分子量:221.73
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:Cl.[H][C@@]12Cc3ccccc3[C@@]([H])(C1)C=C[C@H]2N |c:14,TLB:8:9:12:15.13.14,THB:16:15:12:9.4.3|
SMILES:Cl.[H][C@@]12Cc3ccccc3[C@@]([H])(C1)C=C[C@H]2N |c:14,TLB:8:9:12:15.13.14,THB:16:15:12:9.4.3|

Tylophorine analog Org-6906 is a potential anticancer and immunosuppressive agent. Org-6906 suppresses the translation of cellular regulatory proteins, including cyclin D1, at the elongation step. Org-6906 allosterically regulates the ATPase and chaperone activities of HSC70 by promoting ATP hydrolysis in the presence of specific RNA binding motifs (AUUUA) of cyclin D1 mRNA.

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