Name: ORY-1001 free base
Rating: 5 (10 reviews)

有库存

sdf 文件

结构编辑

类似物检索

HIT ID:HIT214318594
Cas No:1431304-21-0
常用名:ORY-1001 free base
别名:RG-6016, RG6016, RG 6016, ORY-1001, ORY1001, ORY 1001
别名:RG-6016, RG6016, RG 6016, ORY-1001, ORY1001, ORY 1001
IUPAC:(1r,4r)-N1-[(1R,2S)-2-phenylcyclopropyl]cyclohexane-1,4-diamine
IUPAC:(1r,4r)-N1-[(1R,2S)-2-phenylcyclopropyl]cyclohexane-1,4-diamine
InChI key:ALHBJBCQLJZYON-ZQDZILKHSA-N

分子式:C15H22N2
分子量:230.355
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:N[C@H]1CC[C@@H](CC1)N[C@@H]1C[C@H]1c1ccccc1 |wU:8.8,1.0,wD:10.12,4.7,(8.77,1.98,;7.44,1.21,;7.44,-.33,;6.1,-1.1,;4.77,-.33,;4.77,1.21,;6.1,1.98,;3.44,-1.1,;3.44,-2.64,;2.67,-3.97,;4.21,-3.97,;5.54,-4.74,;6.87,-3.97,;8.21,-4.74,;8.21,-6.28,;6.87,-7.05,;5.54,-6.28,)|
SMILES:N[C@H]1CC[C@@H](CC1)N[C@@H]1C[C@H]1c1ccccc1 |wU:8.8,1.0,wD:10.12,4.7,(8.77,1.98,;7.44,1.21,;7.44,-.33,;6.1,-1.1,;4.77,-.33,;4.77,1.21,;6.1,1.98,;3.44,-1.1,;3.44,-2.64,;2.67,-3.97,;4.21,-3.97,;5.54,-4.74,;6.87,-3.97,;8.21,-4.74,;8.21,-6.28,;6.87,-7.05,;5.54,-6.28,)|

ORY-1001 is a KDM1A inhibitor (IC50 <20nM) with high selectivity against related FAD dependent aminoxidases (MAO-A/B, IL4I1, KDM1B >100uM, SMOX 7uM). Treatment of THP-1 (MLL-AF9) cells with ORY-1001, results in a time/dose dependent me2H3K4 accumulation at KDM1A target genes and concomitant induction of differentiation markers (EC50 me2H3K4 and FACS CD11b <1nM). ORY-1001 induces apoptosis in THP-1 and inhibits proliferation and colony formation of MV(4;11) (MLL-AF4) cells (EC50 <1nM). ORY-1001 does not inhibit non-related histone modifiers.

市场产品/服务共显示1个结果

您无法确定哪种化合物库最适合您的项目？或者您需要定制解决方案？Anymole随时为您提供帮助。

电话：400820-0310

合作：info@screeningcompound.com

技术支持：tech@screeningcompound.com

客服：service@screeningcompound.com

正在加载 ~