Name: PD 136450
Rating: 5 (10 reviews)

有库存

sdf 文件

结构编辑

类似物检索

HIT ID:HIT214318607
Cas No:139067-52-0
常用名:PD 136450
别名:PD-136450, PD136450, Cam-1189, Cam1189, Cam 1189
别名:PD-136450, PD136450, Cam-1189, Cam1189, Cam 1189
IUPAC:3-{[(1R)-2-[(2R)-2-({[(1R,3S)-adamantan-2-yloxy]carbonyl}amino)-3-(1H-indol-3-yl)-2-methylpropanamido]-1-phenylethyl]carbamoyl}prop-2-enoic acid
IUPAC:3-{[(1R)-2-[(2R)-2-({[(1R,3S)-adamantan-2-yloxy]carbonyl}amino)-3-(1H-indol-3-yl)-2-methylpropanamido]-1-phenylethyl]carbamoyl}prop-2-enoic acid
InChI key:REMAMJQTIPBFTH-YHTFPLBOSA-N

分子式:C35H40N4O6
分子量:612.727
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:[H]C12CC3([H])C[C@]([H])(C1)[C@H](OC(=O)N[C@](C)(Cc1c[nH]c4ccccc14)C(=O)NC[C@H](NC(=O)C=CC(O)=O)c1ccccc1)[C@]([H])(C2)C3 |w:34.36|
SMILES:[H]C12CC3([H])C[C@]([H])(C1)[C@H](OC(=O)N[C@](C)(Cc1c[nH]c4ccccc14)C(=O)NC[C@H](NC(=O)C=CC(O)=O)c1ccccc1)[C@]([H])(C2)C3 |w:34.36|

Cholecystokinin type B receptor antagonist PD-136,450 is a partial secretory agonist in the stomach and a full agonist in the pancreas of the rat. Gastrin (cholecystokinin type B (CCK-B)) receptor antagonists may help to elucidate the physiological role of gastrin, have therapeutic potential as acid antisecretory drugs, and may be of use as adjuvant therapy for gastrin sensitive tumours. The agonist effect of PD-136,450 is mediated via interaction with the gastrin (CCK-B) receptor in the stomach and the CCK-A receptor in the pancreas.

市场产品/服务共显示1个结果

您无法确定哪种化合物库最适合您的项目？或者您需要定制解决方案？Anymole随时为您提供帮助。

电话：400820-0310

合作：info@screeningcompound.com

技术支持：tech@screeningcompound.com

客服：service@screeningcompound.com

正在加载 ~