Name: MK-0916
Rating: 5 (10 reviews)

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sdf 文件

结构编辑

类似物检索

HIT ID:HIT214319927
Cas No:633317-53-0
常用名:MK-0916
别名:MK 0916
IUPAC:3,4-dicyclopropyl-5-[(1r,3r)-1-(4-chlorophenyl)-3-fluorocyclobutyl]-4H-1,2,4-triazole
IUPAC:3,4-dicyclopropyl-5-[(1r,3r)-1-(4-chlorophenyl)-3-fluorocyclobutyl]-4H-1,2,4-triazole
InChI key:OGYZYOKAXYFLIU-PPUGGXLSSA-N

分子式:C18H19ClFN3
分子量:331.82
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:F[C@H]1C[C@@](C1)(c1nnc(C2CC2)n1C1CC1)c1ccc(Cl)cc1 |wU:3.5,wD:1.0,3.19,(.57,2.77,;-.97,2.65,;-2.14,3.65,;-3.14,2.48,;-1.97,1.48,;-4.04,1.24,;-5.58,1.24,;-6.06,-.23,;-4.81,-1.13,;-4.81,-2.67,;-4.04,-4.01,;-5.58,-4.01,;-3.57,-.23,;-2.1,-.7,;-.6,-.38,;-1.07,-1.85,;-4.51,3.18,;-5.8,2.34,;-7.17,3.04,;-7.25,4.58,;-8.63,5.28,;-5.96,5.42,;-4.59,4.72,)|
SMILES:F[C@H]1C[C@@](C1)(c1nnc(C2CC2)n1C1CC1)c1ccc(Cl)cc1 |wU:3.5,wD:1.0,3.19,(.57,2.77,;-.97,2.65,;-2.14,3.65,;-3.14,2.48,;-1.97,1.48,;-4.04,1.24,;-5.58,1.24,;-6.06,-.23,;-4.81,-1.13,;-4.81,-2.67,;-4.04,-4.01,;-5.58,-4.01,;-3.57,-.23,;-2.1,-.7,;-.6,-.38,;-1.07,-1.85,;-4.51,3.18,;-5.8,2.34,;-7.17,3.04,;-7.25,4.58,;-8.63,5.28,;-5.96,5.42,;-4.59,4.72,)|

MK-0916 is a 11β-hydroxysteroid dehydrogenase type 1 inhibitor indicated for the treatment of type 2 diabetes and metabolic syndrome as well as obesity-related diseases.

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