Name: Quinaldopeptin
Rating: 5 (10 reviews)

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HIT ID:HIT214320521
Cas No:130743-07-6
常用名:Quinaldopeptin
别名:喹哪朵肽
IUPAC:3-hydroxy-N-[27-(3-hydroxyquinoline-2-amido)-4,15,28,39-tetramethyl-2,6,13,16,19,26,30,37,40,43-decaoxo-1,5,12,15,18,25,29,36,39,42-decaazapentacyclo[42.4.0.0^{7,12}.0^{20,25}.0^{31,36}]octatetracontan-3-yl]quinoline-2-carboxamide
IUPAC:3-hydroxy-N-[27-(3-hydroxyquinoline-2-amido)-4,15,28,39-tetramethyl-2,6,13,16,19,26,30,37,40,43-decaoxo-1,5,12,15,18,25,29,36,39,42-decaazapentacyclo[42.4.0.0^{7,12}.0^{20,25}.0^{31,36}]octatetracontan-3-yl]quinoline-2-carboxamide
InChI key:KIPSHYPQCJYONU-UHFFFAOYSA-N

分子式:C62H78N14O14
分子量:1243.39
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:CC1NC(=O)C2CCCCN2C(=O)CN(C)C(=O)CNC(=O)C2CCCCN2C(=O)C(NC(=O)c2nc3ccccc3cc2O)C(C)NC(=O)C2CCCCN2C(=O)CN(C)C(=O)CNC(=O)C2CCCCN2C(=O)C1NC(=O)c1nc2ccccc2cc1O
SMILES:CC1NC(=O)C2CCCCN2C(=O)CN(C)C(=O)CNC(=O)C2CCCCN2C(=O)C(NC(=O)c2nc3ccccc3cc2O)C(C)NC(=O)C2CCCCN2C(=O)CN(C)C(=O)CNC(=O)C2CCCCN2C(=O)C1NC(=O)c1nc2ccccc2cc1O

Quinaldopeptin is a quinomycin antibiotic. It is active against a variety of bacteria, including S. pyogenes, S. aureus, C. perfringens, S. faecalis, E. coli, and K. pneumoniae (MICs = 0.2, 0.4, 0.8, 1.6, 3.1 and 6.3 μg/ml, respectively). It is cytotoxic to B16/F10 and Moser cells (IC50s = 0.0008 and 0.04 μg/ml, respectively) and increases survival in a P388 leukemia mouse model. Quinaldopeptin is a bis-intercalator depsipeptide (NPBID) that binds to and intercalates into DNA (Kd = 32 nM).

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