Name: (±)16-HETE
Rating: 5 (10 reviews)

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HIT ID:HIT214320617
Cas No:128914-46-5
常用名:(±)16-HETE
IUPAC:(5Z,8Z,11Z,14Z)-16-hydroxyicosa-5,8,11,14-tetraenoic acid
IUPAC:(5Z,8Z,11Z,14Z)-16-hydroxyicosa-5,8,11,14-tetraenoic acid
InChI key:JEKNPVYFNMZRJG-UFINWASNSA-N

分子式:C20H32O3
分子量:320.473
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:CCCCC(O)\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O
SMILES:CCCCC(O)\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O

Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites. (±)16-HETE is the racemic version of a minor CYP450 metabolite of arachidonic acid released by the kidney upon angiotensin II stimulation. The biological activity of 16-HETE is stereospecific. 16(R)-HETE dose-dependently stimulates vasodilation of the rabbit kidney, however 16(S)-HETE does not affect perfusion pressure. At a concentration of 2 μM the (S)-enantiomer of 16-HETE inhibits proximal tubule ATPase activity by as much as 60%, whereas the (R)-isomer has negligible effects on ATPase activity.

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