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HIT214320631
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HIT214320631
  • HIT ID:HIT214320631
  • Cas No:895127-64-7
  • 常用名:(±)13(14)-EpDPA
  • IUPAC:(4Z,7Z,10Z)-12-{3-[(2Z,5Z)-octa-2,5-dien-1-yl]oxiran-2-yl}dodeca-4,7,10-trienoic acid
    IUPAC:(4Z,7Z,10Z)-12-{3-[(2Z,5Z)-octa-2,5-dien-1-yl]oxiran-2-yl}dodeca-4,7,10-trienoic acid
  • InChI key:DCFKVKFLEPMEGT-UQZHZJRSSA-N
  • 分子式:C22H32O3
  • 分子量:344.495
  • 氢键供体数 (HBD):
  • 氢键受体数 (HBA):
  • LogP:
  • SMILES:CC\C=C/C\C=C/CC1OC1C\C=C/C\C=C/C\C=C/CCC(O)=O
    SMILES:CC\C=C/C\C=C/CC1OC1C\C=C/C\C=C/C\C=C/CCC(O)=O
  • Cytochrome P450 metabolism of polyunsaturated fatty acids produces numerous bioactive epoxide regioisomers. (±)13(14)-EpDPA is a docosahexaenoic acid epoxygenase metabolite, derived via epoxidation of the 13,14-double bond of DHA. It has been detected in rat brain and spinal cord and is a preferred substrate for soluble epoxide hydrolase with a Km value of 3.2 μM. (±)13(14)-EpDPA demonstrates antihyperalgesic activity in inflammatory and neuropathic pain models. (±)13(14)-EpDPA and other epoxy metabolites of DHA are also reported to potently inhibit angiogenesis and tumor growth in in vitro assays.
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  • 供应商
    TargetMolSC
    规格
    货期
    35日内发货
    纯度
    -
    ¥ 987.00
    1

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