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  3. HIT214320637
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HIT214320637
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HIT214320637
  • HIT ID:HIT214320637
  • Cas No:81187-21-5
  • 常用名:(±)12-HEPE
  • IUPAC:(5Z,8Z,10E,14Z,17Z)-12-hydroxyicosa-5,8,10,14,17-pentaenoic acid
    IUPAC:(5Z,8Z,10E,14Z,17Z)-12-hydroxyicosa-5,8,10,14,17-pentaenoic acid
  • InChI key:MCRJLMXYVFDXLS-QGQBRVLBSA-N
  • 分子式:C20H30O3
  • 分子量:318.457
  • 氢键供体数 (HBD):
  • 氢键受体数 (HBA):
  • LogP:
  • SMILES:CC\C=C/C\C=C/CC(O)\C=C\C=C/C\C=C/CCCC(O)=O
    SMILES:CC\C=C/C\C=C/CC(O)\C=C\C=C/C\C=C/CCCC(O)=O
  • (±)12-HEPE is produced by non-enzymatic oxidation of EPA. It contains equal amounts of 12(S)-HEPE and 12(R)-HEPE. The biological activity of (±)12-HEPE is likely mediated by one of the individual isomers, most commonly the 12(S) isomer in mammalian systems. 12-HEPE inhibits platelet aggregation with the same potency as 12-HETE, exhibiting IC50 values of 24 and 25 &#181M, respectively. [1] These compounds are also equipotent as inhibitors of U46619-induced contraction of rat aorta (IC50s = 8.6-8.8 &#181M).[2]
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  • 供应商
    TargetMolSC
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    货期
    35日内发货
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    ¥ 2,870.00
    1

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