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HIT214320648
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HIT214320648
  • HIT ID:HIT214320648
  • Cas No:1189924-28-4
  • 常用名:Guanfacine-13C,15N3
  • 别名:Guanfacine-13C,15N3
  • IUPAC:N-(15N2)carbamimidoyl-2-(2,6-dichlorophenyl)ethan(15N)amide
    IUPAC:N-(15N2)carbamimidoyl-2-(2,6-dichlorophenyl)ethan(15N)amide
  • InChI key:INJOMKTZOLKMBF-DATIIYMNSA-N
  • 分子式:C9H9Cl2N3O
  • 分子量:250.06
  • 氢键供体数 (HBD):
  • 氢键受体数 (HBA):
  • LogP:
  • SMILES:[15NH2][13C](=[15NH])[15NH]C(=O)Cc1c(Cl)cccc1Cl
    SMILES:[15NH2][13C](=[15NH])[15NH]C(=O)Cc1c(Cl)cccc1Cl
  • Guanfacine-13C,15N3is intended for us as an internal standard for the quantification of guanfacine by GC- or LC-MS. Guanfacine is an α2-adrenergic receptor (α2-AR) agonist with Kivalues of 93, 1,380, and 3,890 nM for α2A-, α2B-, and α2C-ARs, respectively, in a radioligand binding assay.1It has EC50values of 52, 288, and 602 nM for α2A-, α2B-, and α2C-ARs, respectively, for stimulated [35S]GTPγS binding. It also binds to imidazoline receptor 1 (Ki= 19 nM in a radioligand binding assay).2Guanfacine (0.3-5 mg/kg) binds to adrenergic receptors in the central nervous system and lowers blood pressure in hypertensive rats in a dose-dependent manner.3It also improves spatial working memory deficits induced by hypobaric hypoxia in rats.4Formulations containing guanfacine are used in the treatment of high blood pressure and attention deficit hyperactivity disorder (ADHD).
市场产品/服务共显示1个结果
  • 供应商
    TargetMolSC
    规格
    货期
    35日内发货
    纯度
    -
    ¥ 8,400.00
    1

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