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- HIT ID:HIT214320651
- Cas No:128914-47-6
- 常用名:(±)17-HETE
- InChI key:OPPIPPRXLIDJKN-JPURVOHMSA-N
- 分子式:C20H32O3
- 分子量:320.473
- 氢键供体数 (HBD):
- 氢键受体数 (HBA):
- LogP:
- Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites. (±)17-HETE is the racemic version of a cytochrome P450 (CYP450) metabolite of arachidonic acid that has stereospecific effects on sodium transport in the kidney. At a concentration of 2 μM the (S)-enantiomer of 17-HETE inhibits proximal tubule ATPase activity by as much as 70%, whereas the (R)-isomer is inactive.
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