Name: PI3Kα-IN-4
Rating: 5 (10 reviews)

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HIT ID:HIT214320655
Cas No:2322293-83-2
常用名:PI3Kα-IN-4
别名:PI3Kα-IN-4
IUPAC:(2R)-3-{6-[5-(2-chloro-4-fluorobenzenesulfonamido)-6-methoxypyridin-3-yl]-4-oxo-3,4-dihydroquinazolin-3-yl}-N,2-dimethylpropanamide
IUPAC:(2R)-3-{6-[5-(2-chloro-4-fluorobenzenesulfonamido)-6-methoxypyridin-3-yl]-4-oxo-3,4-dihydroquinazolin-3-yl}-N,2-dimethylpropanamide
InChI key:LPATWVFSBNDSHR-CQSZACIVSA-N

分子式:C25H23ClFN5O5S
分子量:560
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:CNC(=O)[C@H](C)Cn1cnc2ccc(cc2c1=O)-c1cnc(OC)c(NS(=O)(=O)c2ccc(F)cc2Cl)c1
SMILES:CNC(=O)[C@H](C)Cn1cnc2ccc(cc2c1=O)-c1cnc(OC)c(NS(=O)(=O)c2ccc(F)cc2Cl)c1

PI3Kα-IN-4 is a potent, selective and orally active inhibitor of PI3Kα, with an IC50 of 1.8 nM. PI3Kα-IN-4 has antitumor activity[1].

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