Name: FD223
Rating: 5 (10 reviews)

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HIT ID:HIT214320659
Cas No:2050524-24-6
常用名:FD223
IUPAC:N-(2-chloro-5-{1H-pyrazolo[3,4-b]pyridin-5-yl}pyridin-3-yl)benzenesulfonamide
IUPAC:N-(2-chloro-5-{1H-pyrazolo[3,4-b]pyridin-5-yl}pyridin-3-yl)benzenesulfonamide
InChI key:VFNUYVJFDQOTNJ-UHFFFAOYSA-N

分子式:C17H12ClN5O2S
分子量:385.83
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:Clc1ncc(cc1NS(=O)(=O)c1ccccc1)-c1cnc2[nH]ncc2c1
SMILES:Clc1ncc(cc1NS(=O)(=O)c1ccccc1)-c1cnc2[nH]ncc2c1

FD223 is a potent and selective phosphoinositide 3-kinase delta (PI3Kδ) inhibitor. FD223 displays high potency (IC50=1 nM) and good selectivity over other isoforms (IC50s of 51 nM, 29 nM and 37 nM, respectively for α, β and γ). FD223 exhibits efficient inhibition of the proliferation of acute myeloid leukemia (AML) cell lines by suppressing p-AKT Ser473 thus causing G1 phase arrest during the cell cycle. FD223 has potential for the research of leukemia such as AML[1].

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