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  3. HIT214320664
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HIT214320664
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HIT214320664
  • HIT ID:HIT214320664
  • Cas No:2247911-68-6
  • 常用名:Lipoxygenin
  • IUPAC:(naphthalen-2-yl)({2',4,6-trimethoxy-[3,3'-bipyridin]-5-yl})methanol
    IUPAC:(naphthalen-2-yl)({2',4,6-trimethoxy-[3,3'-bipyridin]-5-yl})methanol
  • InChI key:OSVNGDATIGOCLA-UHFFFAOYSA-N
  • 分子式:C24H22N2O4
  • 分子量:402.45
  • 氢键供体数 (HBD):
  • 氢键受体数 (HBA):
  • LogP:
  • SMILES:COc1ncccc1-c1cnc(OC)c(C(O)c2ccc3ccccc3c2)c1OC
    SMILES:COc1ncccc1-c1cnc(OC)c(C(O)c2ccc3ccccc3c2)c1OC
  • Lipoxygenin is an inhibitor of 5-lipoxygenase (5-LO) with an IC50value of 5 μM for inhibition of 5-LO product synthesis in isolated human granulocytes stimulated with the cation ionophore A23187 .1It inhibits hedgehog-dependent signaling in Shh-LIGHT2 cells and TGF-β-, activin A-, bone morphogenic protein (BMP)-, or Wnt-dependent signaling in HEK293T cells (IC50s = 9.3, 3.2, 8.2, 9.6, and 3.7 μM, respectively, in luciferase reporter assays). Lipoxygenin (5 and 10 μM) increases levels of troponin T (TnnT), a marker of cardiomyocyte differentiation, in human induced pluripotent stem cells (iPSCs) stimulated with BMP4 and the glycogen synthase kinase 3 (GSK3) inhibitor CHIR99021 .
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  • 供应商
    TargetMolSC
    规格
    货期
    35日内发货
    纯度
    -
    ¥ 1,080.00
    1

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