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  3. HIT214320666
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HIT214320666
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HIT214320666
  • HIT ID:HIT214320666
  • Cas No:2131223-64-6
  • 常用名:YW1128
  • IUPAC:5-methyl-1-(2-methylphenyl)-N-(quinolin-2-yl)-1H-1,2,3-triazole-4-carboxamide
    IUPAC:5-methyl-1-(2-methylphenyl)-N-(quinolin-2-yl)-1H-1,2,3-triazole-4-carboxamide
  • InChI key:SXZFICNOPPNYJM-UHFFFAOYSA-N
  • 分子式:C20H17N5O
  • 分子量:343.39
  • 氢键供体数 (HBD):
  • 氢键受体数 (HBA):
  • LogP:
  • SMILES:Cc1c(nnn1-c1ccccc1C)C(=O)Nc1ccc2ccccc2n1
    SMILES:Cc1c(nnn1-c1ccccc1C)C(=O)Nc1ccc2ccccc2n1
  • YW1128 is an inhibitor of Wnt/β-catenin signaling with an IC50 value of 4.1 nM in a reporter assay.1 It decreases protein levels of β-catenin in the presence of the GSK3β inhibitor lithium chloride and increases protein levels of Axin1 in HEK293 cells. YW1128 decreases lipid accumulation and the expression of gluconeogenic and lipogenic genes in Huh7 cells. It decreases the hepatic expression of Wnt target genes, improves glucose tolerance, and prevents body weight increases and hepatic lipid accumulation in mice fed a high-fat diet, but not mice fed normal chow, when administered at a dose of 40 mg/kg every other day for 11 weeks.
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  • 供应商
    TargetMolSC
    规格
    货期
    35日内发货
    纯度
    -
    ¥ 1,560.00
    1

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