Name: Oleic Acid-2,6-diisopropylanilide
Rating: 5 (10 reviews)

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HIT ID:HIT214320683
Cas No:140112-65-8
常用名:Oleic Acid-2,6-diisopropylanilide
常用名:Oleic Acid-2,6-diisopropylanilide
IUPAC:(9Z)-N-[2,6-bis(propan-2-yl)phenyl]octadec-9-enamide
IUPAC:(9Z)-N-[2,6-bis(propan-2-yl)phenyl]octadec-9-enamide
InChI key:KIULGBCXKSTGQP-YPKPFQOOSA-N

分子式:C30H51NO
分子量:441.744
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:CCCCCCCC\C=C/CCCCCCCC(=O)Nc1c(cccc1C(C)C)C(C)C
SMILES:CCCCCCCC\C=C/CCCCCCCC(=O)Nc1c(cccc1C(C)C)C(C)C

AcylCoA:cholesterol acyltransferase (ACAT) is an intracellular cholesteryl ester synthase tied closely to the absorption of dietary cholesterol. Oleic acid-2,6-diisopropylanilide is an inhibitor of acylCoA:cholesterol acyltransferase with an IC50 of 7 nM. When co-administered to rabbits or rats fed a high fat, high cholesterol diet, oleic acid-2,6-diisopropylanilide decreased low density lipoproteins and elevated high density lipoprotein levels when administered at 0.05%.

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