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  3. HIT214320688
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HIT214320688
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HIT214320688
  • HIT ID:HIT214320688
  • Cas No:922507-80-0
  • 常用名:16F16
  • IUPAC:methyl 2-(2-chloroacetyl)-1-methyl-1H,2H,3H,4H,9H-pyrido[3,4-b]indole-1-carboxylate
    IUPAC:methyl 2-(2-chloroacetyl)-1-methyl-1H,2H,3H,4H,9H-pyrido[3,4-b]indole-1-carboxylate
  • InChI key:BCSIRYFYAKLJDK-UHFFFAOYSA-N
  • 分子式:C16H17ClN2O3
  • 分子量:320.77
  • 氢键供体数 (HBD):
  • 氢键受体数 (HBA):
  • LogP:
  • SMILES:COC(=O)C1(C)N(CCc2c1[nH]c1ccccc21)C(=O)CCl
    SMILES:COC(=O)C1(C)N(CCc2c1[nH]c1ccccc21)C(=O)CCl
  • 16F16 is a protein disulfide isomerase (PDI) inhibitor.1It inhibits PDI reductase activity in an enzyme assay when used at concentrations ranging from 1 to 100 μg/ml.116F16 reduces PC12 cell apoptosis induced by the misfolded huntingtin protein HTTQ103. It suppresses PDI-dependent mitochondrial outer membrane permeabilization (MOMP) in isolated PC12 cell mitochondria. 16F16 (2, 3, 4, and 10 μM) reduces HTTN90Q73mutant huntingtin-induced medium spinal neuron death and MOMP in rat corticostriatal slices. It also reduces pyramidal neuron death induced by amyloid-β precursor protein (APP) in rat corticostriatal slices.
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  • 供应商
    TargetMolSC
    规格
    货期
    35日内发货
    纯度
    -
    ¥ 7,650.00
    1

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