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  3. HIT214320693
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HIT214320693
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HIT214320693
  • HIT ID:HIT214320693
  • Cas No:314245-65-3
  • 常用名:Migrastatin
  • IUPAC:4-[(5S)-5-[(2R,3E,5R,6S,7S,8Z,12Z)-6-hydroxy-7-methoxy-3,5-dimethyl-14-oxo-1-oxacyclotetradeca-3,8,12-trien-2-yl]-4-oxohexyl]piperidine-2,6-dione
    IUPAC:4-[(5S)-5-[(2R,3E,5R,6S,7S,8Z,12Z)-6-hydroxy-7-methoxy-3,5-dimethyl-14-oxo-1-oxacyclotetradeca-3,8,12-trien-2-yl]-4-oxohexyl]piperidine-2,6-dione
  • InChI key:OGYMUMAKGYYNHV-GXMYJGORSA-N
  • 分子式:C27H39NO7
  • 分子量:489.609
  • 氢键供体数 (HBD):
  • 氢键受体数 (HBA):
  • LogP:
  • SMILES:[H][C@@]1(OC(=O)\C=C/CC\C=C/[C@H](OC)[C@@H](O)[C@H](C)\C=C1/C)[C@H](C)C(=O)CCCC1CC(=O)NC(=O)C1 |c:5,9,t:18|
    SMILES:[H][C@@]1(OC(=O)\C=C/CC\C=C/[C@H](OC)[C@@H](O)[C@H](C)\C=C1/C)[C@H](C)C(=O)CCCC1CC(=O)NC(=O)C1 |c:5,9,t:18|
  • Migrastatin is a bacterial metabolite that has been found inStreptomyceswith antimuscarinic and anticancer activities.1,2It binds to M1-5muscarinic acetylcholine receptors (Kis = >200, 200, 31, 43, and >200 μM, respectively) and inhibits calcium mobilization induced by carbamoylcholine in SK-N-SH cells (IC50= 28 μM), as well as in primary rat bladder smooth muscle cells.1Migrastatin inhibits the migration of EC17 esophageal cancer cells in a wound healing assay (IC50= 10 μg/ml) and 4T1 mouse mammary carcinoma cells in a chamber cell migration assay (IC50= 29 μM).2It enhances cytotoxicity induced by vinblastine in vincristine-resistant P388/VCR cells.3
市场产品/服务共显示1个结果
  • 供应商
    TargetMolSC
    规格
    货期
    35日内发货
    纯度
    -
    ¥ 13,200.00
    1

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