Name: rac-trans-4-hydroxy Glyburide
Rating: 5 (10 reviews)

有库存

sdf 文件

结构编辑

类似物检索

HIT ID:HIT214320705
Cas No:23155-00-2
常用名:rac-trans-4-hydroxy Glyburide
IUPAC:5-chloro-2-methoxy-N-(2-{4-[({[(1r,4r)-4-hydroxycyclohexyl]carbamoyl}amino)sulfonyl]phenyl}ethyl)benzamide
IUPAC:5-chloro-2-methoxy-N-(2-{4-[({[(1r,4r)-4-hydroxycyclohexyl]carbamoyl}amino)sulfonyl]phenyl}ethyl)benzamide
InChI key:IUWSGCQEWOOQDN-IYARVYRRSA-N

分子式:C23H28ClN3O6S
分子量:510
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:COc1ccc(Cl)cc1C(=O)NCCc1ccc(cc1)S(=O)(=O)NC(=O)N[C@H]1CC[C@H](O)CC1 |wU:27.28,wD:30.32,(-4,-25.41,;-4,-23.87,;-5.33,-23.1,;-6.67,-23.87,;-8,-23.1,;-8,-21.56,;-9.34,-20.79,;-6.67,-20.79,;-5.33,-21.56,;-4,-20.79,;-2.67,-21.56,;-4,-19.25,;-2.67,-18.48,;-2.67,-16.94,;-1.33,-16.17,;-1.33,-14.63,;,-13.86,;1.33,-14.63,;1.33,-16.17,;,-16.94,;2.67,-13.86,;1.9,-12.53,;3.44,-15.19,;4,-13.09,;5.33,-13.86,;5.33,-15.4,;6.67,-13.09,;8,-13.86,;9.34,-13.09,;10.67,-13.86,;10.67,-15.4,;12,-16.17,;9.34,-16.17,;8,-15.4,)|
SMILES:COc1ccc(Cl)cc1C(=O)NCCc1ccc(cc1)S(=O)(=O)NC(=O)N[C@H]1CC[C@H](O)CC1 |wU:27.28,wD:30.32,(-4,-25.41,;-4,-23.87,;-5.33,-23.1,;-6.67,-23.87,;-8,-23.1,;-8,-21.56,;-9.34,-20.79,;-6.67,-20.79,;-5.33,-21.56,;-4,-20.79,;-2.67,-21.56,;-4,-19.25,;-2.67,-18.48,;-2.67,-16.94,;-1.33,-16.17,;-1.33,-14.63,;,-13.86,;1.33,-14.63,;1.33,-16.17,;,-16.94,;2.67,-13.86,;1.9,-12.53,;3.44,-15.19,;4,-13.09,;5.33,-13.86,;5.33,-15.4,;6.67,-13.09,;8,-13.86,;9.34,-13.09,;10.67,-13.86,;10.67,-15.4,;12,-16.17,;9.34,-16.17,;8,-15.4,)|

rac-trans-4-hydroxy Glyburide is an active metabolite of the SUR1/Kir6.2 sulfonylurea inhibitor glyburide .1,2It is formed from glyburide by the cytochrome P450 (CYP) isoforms CYP2C8 and CYP2C9.1rac-trans-4-hydroxy Glyburide inhibits glyburide binding to rat brain synaptosomes at the high and low affinity sites of SUR1/Kir6.2 with IC50values of 0.95 and 100 nM, respectively.2

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