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- HIT ID:HIT214320710
- Cas No:103560-62-9
- 常用名:4-oxo-2-Nonenal
- 别名:4-oxo-2-Nonenal, 4-ONE
- InChI key:SEPPVOUBHWNCAW-FNORWQNLSA-N
- 分子式:C9H14O2
- 分子量:154.209
- 氢键供体数 (HBD):
- 氢键受体数 (HBA):
- LogP:
- 4-hydroxy Nonenal is a lipid peroxidation product derived from oxidized ω-6 polyunsaturated fatty acids such as arachidonic acid and linoleic acid. [1] [2] It exhibits various biological activities such as cytotoxicity, growth inhibiting activity, genotoxicity, and chemotactic activity and has been widely used as a marker of lipid peroxidation.[1][2][3] 4-oxo-2-Nonenal is a more recently identified product of lipid peroxidation.[4][5][6] It actively modifies histidine and lysine residues on proteins and causes protein cross-linking. [7][8] 4-oxo-2-Nonenal also modifies 2’-deoxyguanosine, further implicating lipid peroxidation in mutagenesis and carcinogenesis.[4]
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