Name: 2'2'-cGAMP (sodium salt)
Rating: 5 (10 reviews)

有库存

sdf 文件

结构编辑

类似物检索

HIT ID:HIT214320713
Cas No:1465774-27-9
常用名:2'2'-cGAMP (sodium salt)
IUPAC:(1R,6R,8R,9R,14R,16R,18R)-8-(2-amino-6-oxo-6,9-dihydro-3H-purin-9-yl)-16-(6-amino-9H-purin-9-yl)-3,11,17,18-tetrahydroxy-2,4,7,10,12,15-hexaoxa-3lambda5,11lambda5-diphosphatricyclo[12.2.1.1^{6,9}]octadecane-3,11-dione
IUPAC:(1R,6R,8R,9R,14R,16R,18R)-8-(2-amino-6-oxo-6,9-dihydro-3H-purin-9-yl)-16-(6-amino-9H-purin-9-yl)-3,11,17,18-tetrahydroxy-2,4,7,10,12,15-hexaoxa-3lambda5,11lambda5-diphosphatricyclo[12.2.1.1^{6,9}]octadecane-3,11-dione
InChI key:BQZWXNITEWDGCM-WGKJRFPRSA-N

分子式:C20H24N10O13P2
分子量:674.417
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:[H][C@]12COP(O)(=O)O[C@@]3([H])[C@@H](O[C@]([H])(COP(O)(=O)O[C@@]([H])([C@@H](O1)n1cnc4c(N)ncnc14)C2O)[C@H]3O)n1cnc2c1[nH]c(N)nc2=O
SMILES:[H][C@]12COP(O)(=O)O[C@@]3([H])[C@@H](O[C@]([H])(COP(O)(=O)O[C@@]([H])([C@@H](O1)n1cnc4c(N)ncnc14)C2O)[C@H]3O)n1cnc2c1[nH]c(N)nc2=O

2'2'-cGAMP is a synthetic dinucleotide (CDN) that contains non-canonical 2'5'-phosphodiester bonds. It binds to the adapter protein stimulator of interferon genes , which is a component of the innate immune response that activates the type I interferon pathway when bound to cyclic dinucleotides. 2'2-cGAMP shows weaker binding to STING than 2'3'-cGAMP but binds more strongly than 3'3'-cGAMP , cyclic di-GMP , or 3'2'-cGAMP, which bind in the micromolar range (Kds = 1.04, 1.21, or 1.61 μM, respectively). Despite weaker binding, 2'2'-cGAMP induces IFN-β production in the same concentration range as 2'3'-cGAMP (EC50s = 15.8 and 19.4 nM, respectively, in L929 cells).

市场产品/服务共显示1个结果

您无法确定哪种化合物库最适合您的项目？或者您需要定制解决方案？Anymole随时为您提供帮助。

电话：400820-0310

合作：info@screeningcompound.com

技术支持：tech@screeningcompound.com

客服：service@screeningcompound.com

正在加载 ~