Name: Cortistatin-29 (rat) (trifluoroacetate salt)
Rating: 5 (10 reviews)

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HIT ID:HIT214320718
Cas No:1815618-17-7
常用名:Cortistatin-29 (rat) (trifluoroacetate salt)
常用名:Cortistatin-29 (rat) (trifluoroacetate salt)
IUPAC:(2S)-6-amino-2-{[(4R,7S,10S,13S,16S,19S,22S,25S,28S,31S,34S,37R)-37-[(2S)-1-[(2S)-6-amino-2-[(2S)-6-amino-2-[(2S)-2-[(2S)-5-carbamimidamido-2-[(2S)-2-{[(2S)-1-[(2S)-1-[(2S)-2-[(2S)-2-[(2S)-2-{[(2S)-1-[(2S)-1-[(2S)-5-carbamimidamido-2-[(2S)-4-carboxy-2-{[(2S)-5-oxopyrrolidin-2-yl]formamido}butanamido]pentanoyl]pyrrolidine-2-carbonyl]pyrrolidin-2-yl]formamido}-4-methylpentanamido]-4-carbamoylbutanamido]-4-carbamoylbutanoyl]pyrrolidine-2-carbonyl]pyrrolidin-2-yl]formamido}-3-(1H-imidazol-5-yl)propanamido]pentanamido]-3-carboxypropanamido]hexanamido]hexanoyl]pyrrolidine-2-amido]-19,34-bis(4-aminobutyl)-13,25,28-tribenzyl-31-(carbamoylmethyl)-16-[(1R)-1-hydroxyethyl]-7,10-bis(hydroxymethyl)-22-[(1H-indol-3-yl)methyl]-6,9,12,15,18,21,24,27,30,33,36-undecaoxo-1,2-dithia-5,8,11,14,17,20,23,26,29,32,35-undecaazacyclooctatriacontan-4-yl]formamido}hexanoic acid
IUPAC:(2S)-6-amino-2-{[(4R,7S,10S,13S,16S,19S,22S,25S,28S,31S,34S,37R)-37-[(2S)-1-[(2S)-6-amino-2-[(2S)-6-amino-2-[(2S)-2-[(2S)-5-carbamimidamido-2-[(2S)-2-{[(2S)-1-[(2S)-1-[(2S)-2-[(2S)-2-[(2S)-2-{[(2S)-1-[(2S)-1-[(2S)-5-carbamimidamido-2-[(2S)-4-carboxy-2-{[(2S)-5-oxopyrrolidin-2-yl]formamido}butanamido]pentanoyl]pyrrolidine-2-carbonyl]pyrrolidin-2-yl]formamido}-4-methylpentanamido]-4-carbamoylbutanamido]-4-carbamoylbutanoyl]pyrrolidine-2-carbonyl]pyrrolidin-2-yl]formamido}-3-(1H-imidazol-5-yl)propanamido]pentanamido]-3-carboxypropanamido]hexanamido]hexanoyl]pyrrolidine-2-amido]-19,34-bis(4-aminobutyl)-13,25,28-tribenzyl-31-(carbamoylmethyl)-16-[(1R)-1-hydroxyethyl]-7,10-bis(hydroxymethyl)-22-[(1H-indol-3-yl)methyl]-6,9,12,15,18,21,24,27,30,33,36-undecaoxo-1,2-dithia-5,8,11,14,17,20,23,26,29,32,35-undecaazacyclooctatriacontan-4-yl]formamido}hexanoic acid
InChI key:GQJOQLQAIUKBOS-IOHUZKHFSA-N

分子式:C161H240N46O41S2
分子量:3540.09
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:[H][C@]1(NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](Cc2ccccc2)NC1=O)C(=O)N[C@@H](CCCCN)C(O)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)O
SMILES:[H][C@]1(NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](Cc2ccccc2)NC1=O)C(=O)N[C@@H](CCCCN)C(O)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)O

Cortistatin-29 is a neuropeptide that is structurally similar to somatostatin-28. It is produced by cleavage of preprocortistatin to procortistatin, which is cleaved at dibasic amino acids to form cortistatin-29 and cortistatin-14 as well as other partial cleavage products. Cortistatin mRNA is expressed in the human brain and in interneurons of the rat hippocampus and cerebral cortex. Cortistatin-29 binds to somatostatin (SST) receptors with IC50 values of 2.8, 7.1, 0.2, 3, and 13.7 nM for SST1-5, respectively. Cortistatin-29 is found at similar levels as cortistatin-14 in mouse AtT20 cells but is secreted at a lower level. Cortistatin-29 corresponds to residues 85-112 of the rat peptide sequence.

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