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  3. HIT214320724
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HIT214320724
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HIT214320724
  • HIT ID:HIT214320724
  • Cas No:59795-94-7
  • 常用名:Neoaureothin
  • IUPAC:2-methoxy-3,5-dimethyl-6-[(2R,4Z)-4-[(2E,4E,6E)-2,4,6-trimethyl-7-(4-nitrophenyl)hepta-2,4,6-trien-1-ylidene]oxolan-2-yl]-4H-pyran-4-one
    IUPAC:2-methoxy-3,5-dimethyl-6-[(2R,4Z)-4-[(2E,4E,6E)-2,4,6-trimethyl-7-(4-nitrophenyl)hepta-2,4,6-trien-1-ylidene]oxolan-2-yl]-4H-pyran-4-one
  • InChI key:IZICQJAGBLBAMJ-QDYRYYKCSA-N
  • 分子式:C28H31NO6
  • 分子量:477.557
  • 氢键供体数 (HBD):
  • 氢键受体数 (HBA):
  • LogP:
  • SMILES:COc1oc([C@H]2C\C(CO2)=C\C(\C)=C\C(\C)=C\C(\C)=C\c2ccc(cc2)N(=O)=O)c(C)c(=O)c1C
    SMILES:COc1oc([C@H]2C\C(CO2)=C\C(\C)=C\C(\C)=C\C(\C)=C\c2ccc(cc2)N(=O)=O)c(C)c(=O)c1C
  • Neoaureothin is a bacterial metabolite that has been found in Streptomyces. It is an androgen receptor (AR) antagonist that inhibits binding of dihydrotestosterone (DHT) to ARs (IC50 = 13 μM) and inhibits DHT-induced expression of prostate-specific antigen in LNCaP cells (IC50 = 1.75 nM). Neoaureothin is cytotoxic to A549, HCT116, and HepG2 cells (IC50s = 34.3, 47, and 37.2 μg/ml, respectively). It also has nematocidal activity against the pine wood nematode B. xylophilus (LC50 = 0.84 μg/ml) and increases survival of P. densiflora trees inoculated with B. xylophilus.
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  • 供应商
    TargetMolSC
    规格
    货期
    35日内发货
    纯度
    -
    ¥ 26,900.00
    1

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