Name: Debutyldronedarone hydrochloride
Rating: 5 (10 reviews)

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HIT ID:HIT214320740
Cas No:197431-02-0
常用名:Debutyldronedarone hydrochloride
常用名:Debutyldronedarone hydrochloride
别名:SR35021 hydrochloride
IUPAC:N-(2-butyl-3-{4-[3-(butylamino)propoxy]benzoyl}-1-benzofuran-5-yl)methanesulfonamide hydrochloride
IUPAC:N-(2-butyl-3-{4-[3-(butylamino)propoxy]benzoyl}-1-benzofuran-5-yl)methanesulfonamide hydrochloride
InChI key:ZDXBTJLIQYUYSZ-UHFFFAOYSA-N

分子式:C27H37ClN2O5S
分子量:537.11
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:Cl.CCCCNCCCOc1ccc(cc1)C(=O)c1c(CCCC)oc2ccc(NS(C)(=O)=O)cc12
SMILES:Cl.CCCCNCCCOc1ccc(cc1)C(=O)c1c(CCCC)oc2ccc(NS(C)(=O)=O)cc12

N-Desbutyl dronedarone is an active metabolite of the antiarrhythmic agent dronedarone .1,2,3It is formed from dronedarone by cytochrome P450s (CYPs) and monoamine oxidase (MAO) in human hepatocyte preparations.4N-Desbutyl dronedarone inhibits the binding of 3,3’,5-triiodo-L-thyronine to the thyroid hormone receptors TRα1and TRβ1(IC50s = 59 and 280 μM for the chicken and human receptors, respectively).1It inhibits CYP2J2-mediated formation of 14,15-EET from arachidonic acid and soluble epoxide hydrolase-mediated formation of 14,15-DHET from 14,15-EET (IC50s = 1.59 and 2.73 μM, respectively, in cell-free assays).2N-Desbutyl dronedarone decreases intracellular ATP levels in H9c2 rat cardiomyocytes (IC50= 1.07 μM) and inhibits mitochondrial complex I, also known as NADH dehydrogenase, and mitochondrial complex II, also known as succinate dehydrogenase, activities in isolated rat heart mitochondria (IC50s = 11.94 and 24.54 μM, respectively).3

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