Name: Marcfortine A
Rating: 5 (10 reviews)

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HIT ID:HIT214320758
Cas No:75731-43-0
常用名:Marcfortine A
IUPAC:(1'S,8R,8'S,10'S)-4,4,11',11',14'-pentamethyl-9,10-dihydro-4H-3',14'-diazaspiro[[1,4]dioxepino[2,3-g]indole-8,12'-tetracyclo[6.5.2.0^{1,10}.0^{3,8}]pentadecane]-9,15'-dione
IUPAC:(1'S,8R,8'S,10'S)-4,4,11',11',14'-pentamethyl-9,10-dihydro-4H-3',14'-diazaspiro[[1,4]dioxepino[2,3-g]indole-8,12'-tetracyclo[6.5.2.0^{1,10}.0^{3,8}]pentadecane]-9,15'-dione
InChI key:KYKUTNUWXQVSSU-ZALBMCOMSA-N

分子式:C28H35N3O4
分子量:477.605
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:[H][C@@]12C[C@]34CCCCN3C[C@@]1(C[C@@]1(C(=O)Nc3c1ccc1OC(C)(C)C=COc31)C2(C)C)N(C)C4=O |c:28,@:29,THB:29:1:8.9:32.34|
SMILES:[H][C@@]12C[C@]34CCCCN3C[C@@]1(C[C@@]1(C(=O)Nc3c1ccc1OC(C)(C)C=COc31)C2(C)C)N(C)C4=O |c:28,@:29,THB:29:1:8.9:32.34|

Marcfortine A is an indole alkaloid originally isolated from P. roqueforti. It has nematocidal activity against the parasitic nematode H. contortus (LD99 = 0.06 μg/ml) and inhibits motility of adult worms (EC50 = 2 μM)., Marcfortine A eliminates H. contortus, T. colubriformis, and O. ostertagi from experimentally infected jirds (ED95s = 0.33, 0.11, and 2.5 mg/animal, respectively). It dose-dependently inhibits nicotine-induced calcium mobilization in SH-SY5Y and TE-671 cells expressing α3 subunit-containing human nicotinic acetylcholine receptors (nAChRs) and muscle-type nAChRs, respectively.

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