Name: Aszonapyrone A
Rating: 5 (10 reviews)

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结构编辑

类似物检索

HIT ID:HIT214320764
Cas No:83103-08-6
常用名:Aszonapyrone A
IUPAC:(2S,4aR,4bS,8R,8aS,10aR)-8-[(4-hydroxy-6-methyl-2-oxo-2H-pyran-3-yl)methyl]-1,1,4a,8a-tetramethyl-7-methylidene-tetradecahydrophenanthren-2-yl acetate
IUPAC:(2S,4aR,4bS,8R,8aS,10aR)-8-[(4-hydroxy-6-methyl-2-oxo-2H-pyran-3-yl)methyl]-1,1,4a,8a-tetramethyl-7-methylidene-tetradecahydrophenanthren-2-yl acetate
InChI key:QZWJQNIIRYNONX-NEKODSHDSA-N

分子式:C28H40O5
分子量:456.623
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:[H][C@@]12CC[C@@]3(C)[C@H](Cc4c(O)cc(C)oc4=O)C(=C)CC[C@]3([H])[C@@]1(C)CC[C@H](OC(C)=O)C2(C)C
SMILES:[H][C@@]12CC[C@@]3(C)[C@H](Cc4c(O)cc(C)oc4=O)C(=C)CC[C@]3([H])[C@@]1(C)CC[C@H](OC(C)=O)C2(C)C

Aszonapyrone A is a meroditerpene fungal metabolite that has been found in Neosartorya and has diverse biological activities.1,2,3 It inhibits the growth of MCF-7, NCI H460, and A375-C5 cancer cells (GI50s = 13.6, 11.6, and 10.2 μM, respectively).1 Aszonapyrone A is active against multidrug-resistant isolates of S. aureus, E. faecalis, and E. faecium (MICs = 8, 16, and 16 μg/ml, respectively) and inhibits S. aureus biofilm formation.2 It is also active against P. falciparum in vitro (IC50 = 1.34 μg/ml).3

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