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  3. HIT214320794
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HIT214320794
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HIT214320794
  • HIT ID:HIT214320794
  • Cas No:596104-94-8
  • 常用名:CAY10410
  • IUPAC:(5Z)-7-[(1R,2E)-2-[(2Z)-oct-2-en-1-ylidene]-3-oxocyclopentyl]hept-5-enoic acid
    IUPAC:(5Z)-7-[(1R,2E)-2-[(2Z)-oct-2-en-1-ylidene]-3-oxocyclopentyl]hept-5-enoic acid
  • InChI key:AFBJLDUEEOOVHL-WKELIDJCSA-N
  • 分子式:C20H30O3
  • 分子量:318.457
  • 氢键供体数 (HBD):
  • 氢键受体数 (HBA):
  • LogP:
  • SMILES:CCCCC\C=C/C=C1\[C@@H](C\C=C/CCCC(O)=O)CCC1=O
    SMILES:CCCCC\C=C/C=C1\[C@@H](C\C=C/CCCC(O)=O)CCC1=O
  • CAY10410 is an analog of prostaglandin D2/prostaglandin J2 (PGD2/PGJ2) with structural modifications intended to give it PPARγ ligand activity and resistance to metabolism. 15-deoxy-δ12,14-PGJ2 has been shown to be a potent ligand for PPARγ. Metabolism of the cyclopentenone prostaglandins PGA2, PGJ2, and δ12-PGJ2 occurs via glutathione addition across the α,β unsaturated enone. CAY10410 was designed as an analog of the PPARγ-binding prostaglandins which could not undergo this conjugation reaction. In human neuroblastoma SH-SY5Y cells, CAY10410 was not cytotoxic at up to 25 μM. It also failed to covalently modify thioredoxin or induce oxidative stress at 50 μM.
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  • 供应商
    TargetMolSC
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    35日内发货
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    -
    ¥ 4,130.00
    1

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