Name: CAY10669
Rating: 5 (10 reviews)

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sdf 文件

结构编辑

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HIT ID:HIT214320795
Cas No:1243583-88-1
常用名:CAY10669
IUPAC:2-hydroxy-6-[(1Z)-2-[4-(pentyloxy)phenyl]ethenyl]benzoic acid
IUPAC:2-hydroxy-6-[(1Z)-2-[4-(pentyloxy)phenyl]ethenyl]benzoic acid
InChI key:JZTUSBQKQHUSQE-FLIBITNWSA-N

分子式:C20H22O4
分子量:326.392
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:CCCCCOc1ccc(\C=C/c2cccc(O)c2C(O)=O)cc1
SMILES:CCCCCOc1ccc(\C=C/c2cccc(O)c2C(O)=O)cc1

CAY10669 is an inhibitor of the histone acetyltransferase PCAF (p300/CREB-binding protein-associated factor; IC50 = 662 μM), displaying a 2-fold improvement in inhibitory potency over anacardic acid . At 30-60 μM, CAY10669 can dose-dependently inhibit histone H4 acetylation in HepG2 cells in vitro.

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