Name: ZLY032
Rating: 5 (10 reviews)

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HIT ID:HIT214320798
Cas No:2314465-67-1
常用名:ZLY032
IUPAC:2-[(3S)-6-({4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}methoxy)-2,3-dihydro-1-benzofuran-3-yl]acetic acid
IUPAC:2-[(3S)-6-({4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}methoxy)-2,3-dihydro-1-benzofuran-3-yl]acetic acid
InChI key:YBBZJHLFUPKHJD-CQSZACIVSA-N

分子式:C22H18F3NO4S
分子量:449.44
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:Cc1nc(sc1COc1ccc2[C@H](CC(O)=O)COc2c1)-c1ccc(cc1)C(F)(F)F
SMILES:Cc1nc(sc1COc1ccc2[C@H](CC(O)=O)COc2c1)-c1ccc(cc1)C(F)(F)F

ZLY032 is a dual agonist of free fatty acid receptor 1 (FFAR1/GPR40; EC50= 68 nM in a FLIPR assay) and peroxisome proliferator-activated receptor δ (PPARδ; EC50= 102 nM in a reporter assay).1It is selective for FFAR1 and PPARδ over PPARα and PPARγ (EC50s = >10 μM for both). ZLY032 (40 mg/kg, twice per day) reduces blood glucose levels in an oral glucose tolerance test and decreases plasma total cholesterol and triglyceride levels in theob/obmouse model of metabolic disease.2It reduces hepatic steatosis and plasma alanine transaminase (ALT) and aspartate aminotransferase (AST) levels in a mouse model of non-alcoholic steatohepatitis (NASH) induced by a methionine and choline-deficient diet at the same dose.

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