Name: CC-90005
Rating: 5 (10 reviews)

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HIT ID:HIT214320805
Cas No:1799574-70-1
常用名:CC-90005
IUPAC:2-({[4-(2,2-difluoropropoxy)pyrimidin-5-yl]methyl}amino)-4-{[(1R,4S)-4-hydroxy-3,3-dimethylcyclohexyl]amino}pyrimidine-5-carbonitrile
IUPAC:2-({[4-(2,2-difluoropropoxy)pyrimidin-5-yl]methyl}amino)-4-{[(1R,4S)-4-hydroxy-3,3-dimethylcyclohexyl]amino}pyrimidine-5-carbonitrile
InChI key:FMKGJQHNYMWDFJ-CVEARBPZSA-N

分子式:C21H27F2N7O2
分子量:447.491
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:CC(F)(F)COc1ncncc1CNc1ncc(C#N)c(N[C@@H]2CC[C@H](O)C(C)(C)C2)n1
SMILES:CC(F)(F)COc1ncncc1CNc1ncc(C#N)c(N[C@@H]2CC[C@H](O)C(C)(C)C2)n1

CC-90005 is a potent, selective and orally active inhibitor of protein kinase C-θ (PKC-θ), with an IC50 of 8 nM. CC-90005 shows selectivity for PKC-θ over PKC-δ (IC50=4440 nM). CC-90005 can inhibit T cell activation by IL-2 expression[1].

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