Name: T-5342126
Rating: 5 (10 reviews)

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HIT ID:HIT214320829
Cas No:956507-49-6
常用名:T-5342126
IUPAC:1-[({1-[(2-chlorophenyl)methyl]-3,5-dimethyl-1H-pyrazol-4-yl}methyl)(methyl)amino]-3-(4-ethoxyphenoxy)propan-2-ol
IUPAC:1-[({1-[(2-chlorophenyl)methyl]-3,5-dimethyl-1H-pyrazol-4-yl}methyl)(methyl)amino]-3-(4-ethoxyphenoxy)propan-2-ol
InChI key:UOKIJOWYTBNPIM-UHFFFAOYSA-N

分子式:C25H32ClN3O3
分子量:458
氢键供体数 (HBD):1
氢键受体数 (HBA):5
LogP:5.033
SMILES:CCOc1ccc(OCC(O)CN(C)Cc2c(C)nn(Cc3ccccc3Cl)c2C)cc1
SMILES:CCOc1ccc(OCC(O)CN(C)Cc2c(C)nn(Cc3ccccc3Cl)c2C)cc1

T-5342126 is a toll-like receptor 4 (TLR4) antagonist.1It reduces LPS-induced production of nitric oxide (NO) in RAW 264.7 cells (IC50= 27.8 μM), as well as decreases LPS-induced IL-8, TNF-α, and IL-6 production in isolated human whole blood (IC50s = 110.5, 315.6, and 318.4 μM, respectively). T-5342126 (82 mg/kg) reduces ethanol intake and the abundance of ionized calcium-binding adapter molecule 1 (Iba1), a marker of microglial activation, in the central nucleus of the amygdala in ethanol-dependent mice.2

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