PB1 | CAS 188714-28-5 | AnyMole

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HIT214320843

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HIT214320843

HIT ID:HIT214320843
Cas No:188714-28-5
常用名:PB1
IUPAC:bis(3-methoxy-3-oxopropyl)(phenyl)(trihydrogeniuide-lambda1-boranetriiumyl)-lambda5-phosphanyl
IUPAC:bis(3-methoxy-3-oxopropyl)(phenyl)(trihydrogeniuide-lambda1-boranetriiumyl)-lambda5-phosphanyl
InChI key:DJMCFCYAJQEKGN-UHFFFAOYSA-N

分子式:C14H22BO4P
分子量:296.11
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:[H-][B+3]([H-])([H-])[P](CCC(=O)OC)(CCC(=O)OC)c1ccccc1 |^1:4|
SMILES:[H-][B+3]([H-])([H-])[P](CCC(=O)OC)(CCC(=O)OC)c1ccccc1 |^1:4|

PB1 is a highly-effective intracellular disulfide reducing agent with notable attributes such as excellent cell permeability, the capacity to generate a substantial intracellular concentration gradient, and remarkable stability. It serves as a borane-protected TCEP (tris(2-carboxyethyl)phosphine) analogue. PB1 demonstrates the potential to enhance the survival of retinal ganglion cells following axotomy in vitro at concentrations in the nanomolar and picomolar range. Consequently, PB1 has proven instrumental in the study of neuroprotective properties[1][2][3].

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