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- HIT ID:HIT214320854
- Cas No:119290-12-9
- 常用名:O-11
- InChI key:HSRAJJQTYQHRSA-UHFFFAOYSA-N
- 分子式:C13H26O3
- 分子量:230.348
- 氢键供体数 (HBD):
- 氢键受体数 (HBA):
- LogP:
- O-11 is an analog of the fully saturated, 14-carbon fatty acid myristic acid, in which the methylene group at position 11 is replaced with oxygen. It is highly effective and selective at killingTrypanosoma brucei, the protozoan parasite responsible for African sleeping sickness, exhibiting an LD50of less than 1 μM in a cell culture assay.1,2The toxic effects of O-11 appear to be caused by its ability to inhibit the incorporation of a single myristate into the GPI anchor of the variant surface glycoprotein (VSG), a protein critical for evading the host immune response.1O-11 exhibits essentially no anti-fungal activity when assayed usingC. neoformans, but does have a minor inhibitory effect on HIV-1 replication in T-lymphocytes.3
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