Name: PAR2 (1-6) amide (human) (trifluoroacetate salt)
Rating: 5 (10 reviews)

有库存

sdf 文件

结构编辑

类似物检索

HIT ID:HIT214320888
Cas No:2379569-17-0
常用名:PAR2 (1-6) amide (human) (trifluoroacetate salt)
常用名:PAR2 (1-6) amide (human) (trifluoroacetate salt)
别名:PAR2 (1-6) amide (human) (trifluoroacetate salt)
别名:PAR2 (1-6) amide (human) (trifluoroacetate salt)
IUPAC:(2S)-6-amino-2-{2-[(2R,3S)-2-[(2S)-2-[(2S)-2-amino-3-hydroxypropanamido]-4-methylpentanamido]-3-methylpentanamido]acetamido}-N-[(1S)-1-carbamoyl-2-methylpropyl]hexanamide; trifluoroacetic acid
IUPAC:(2S)-6-amino-2-{2-[(2R,3S)-2-[(2S)-2-[(2S)-2-amino-3-hydroxypropanamido]-4-methylpentanamido]-3-methylpentanamido]acetamido}-N-[(1S)-1-carbamoyl-2-methylpropyl]hexanamide; trifluoroacetic acid
InChI key:HZTZARICKSBEFA-HFNUGOHGSA-N

分子式:C30H55F3N8O9
分子量:728.812
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:OC(=O)C(F)(F)F.CC[C@H](C)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CO)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(N)=O
SMILES:OC(=O)C(F)(F)F.CC[C@H](C)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CO)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(N)=O

PAR2 (1-6) amide is a synthetic peptide agonist of proteinase-activated receptor 2 (PAR2) that corresponds to residues 1-6 of the amino terminal tethered ligand sequence of human PAR2 and residues 37-42 of the full-length sequence.1It binds to NCTC 2544 cells expressing human PAR2 (Ki= 9.64 μM in a radioligand binding assay) and induces calcium mobilization in the same cells (EC50= 0.075 μM).2PAR2 (1-6) amide (100 μM) reduces colony formation of A549 lung cancer cells.1It induces superoxide production and degranulation in isolated human eosinophils when used at a concentration of 500 μM.3PAR2 (1-6) amide (5 μmol/kg) induces tear secretion in rats when used in combination with amastatin .4

市场产品/服务共显示1个结果

您无法确定哪种化合物库最适合您的项目？或者您需要定制解决方案？Anymole随时为您提供帮助。

电话：400820-0310

合作：info@screeningcompound.com

技术支持：tech@screeningcompound.com

客服：service@screeningcompound.com

正在加载 ~