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  3. HIT214320891
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HIT214320891
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HIT214320891
  • HIT ID:HIT214320891
  • Cas No:652968-37-1
  • 常用名:MitoPBN
  • IUPAC:(4-{4-[(tert-butyl-oxo-$l^{5}-azanylidene)methyl]phenoxy}butyl)triphenylphosphanium bromide
    IUPAC:(4-{4-[(tert-butyl-oxo-$l^{5}-azanylidene)methyl]phenoxy}butyl)triphenylphosphanium bromide
  • InChI key:JZMWLDMVLIVXEF-KWYZZNRTSA-M
  • 分子式:C33H37BrNO2P
  • 分子量:590.542
  • 氢键供体数 (HBD):
  • 氢键受体数 (HBA):
  • LogP:
  • SMILES:[Br-].CC(C)(C)N(=O)=Cc1ccc(OCCCC[P+](c2ccccc2)(c2ccccc2)c2ccccc2)cc1
    SMILES:[Br-].CC(C)(C)N(=O)=Cc1ccc(OCCCC[P+](c2ccccc2)(c2ccccc2)c2ccccc2)cc1
  • MitoPBN is a mitochondria-targeted antioxidant. It accumulates in the mitochondria following the generation of a mitochondrial membrane potential by succinate, an effect that is blocked by addition of the mitochondrial membrane potential uncoupler FCCP . MitoPBN inhibits superoxide activation of mitochondrial uncoupling protein 1 (UCP1), UCP2, and UCP3 when used at a concentration of 250 nM in vitro but does not react with superoxide. It traps hydroxyl (IC50 = ~77 μM) and carbon-centered radicals and inhibits the initiation of lipid peroxidation in isolated bovine heart mitochondria.
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  • 供应商
    TargetMolSC
    规格
    货期
    35日内发货
    纯度
    -
    ¥ 10,600.00
    1

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