Name: 4-hydroxy Nonenal Mercapturic Acid
Rating: 5 (10 reviews)

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HIT ID:HIT214320894
Cas No:146764-24-1
常用名:4-hydroxy Nonenal Mercapturic Acid
常用名:4-hydroxy Nonenal Mercapturic Acid
IUPAC:(2R)-2-acetamido-3-[(5-hydroxy-2-pentyloxolan-3-yl)sulfanyl]propanoic acid
IUPAC:(2R)-2-acetamido-3-[(5-hydroxy-2-pentyloxolan-3-yl)sulfanyl]propanoic acid
InChI key:DEWNQQSQBYUUAE-DCNVRKPOSA-N

分子式:C14H25NO5S
分子量:319.42
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:CCCCCC1OC(O)CC1SC[C@H](NC(C)=O)C(O)=O
SMILES:CCCCCC1OC(O)CC1SC[C@H](NC(C)=O)C(O)=O

Peroxidation of common ω-6 polyunsaturated fatty acids (PUFAs) such as linoleic acid, DGLA, and arachidonic acid can give rise to 4-HNE. 4-HNE is cleared rapidly from the plasma and undergoes enterohepatic circulation as a glutathione conjugate in the rat. About two thirds of an administered dose of 4-HNE is excreted within 48 hours in the urine, primarily in the form of mercapturic acid conjugates. The C-1 aldehyde of 4-HNE is reduced to an alcohol in about half of these metabolites. The remainder are C-1 aldehydes or have been oxidized to C-1 carboxylic acids. These aldehydes and carboxylic acids can also form γ-lactols and γ-lactones, respectively, producing at least 4 or 5 end urinary metabolites of 4-HNE in vivo.

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