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  3. HIT214320899
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HIT214320899
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HIT214320899
  • HIT ID:HIT214320899
  • Cas No:778624-05-8
  • 常用名:CAY10487
  • IUPAC:methyl (2S)-2-[(2E)-3-(3,4-dihydroxyphenyl)prop-2-enamido]propanoate
    IUPAC:methyl (2S)-2-[(2E)-3-(3,4-dihydroxyphenyl)prop-2-enamido]propanoate
  • InChI key:WFBBISJLIGYSGF-JQTRYQTASA-N
  • 分子式:C13H15NO5
  • 分子量:265.265
  • 氢键供体数 (HBD):
  • 氢键受体数 (HBA):
  • LogP:
  • SMILES:COC(=O)[C@H](C)NC(=O)\C=C\c1ccc(O)c(O)c1
    SMILES:COC(=O)[C@H](C)NC(=O)\C=C\c1ccc(O)c(O)c1
  • The early stage of atherosclerosis is characterized by the aggregation of foam cells, so called a fatty streak, in the inner arterial wall. CAY10487 inhibits formation of fatty streak lesions of the thoracic aorta in high cholesterol-fed rabbits without affecting plasma lipid profiles or significantly inhibiting ACAT-1 or ACAT-2 activity. The percent area occupied by the atherosclerotic lesion in rabbits supplemented with 0.05% CAY10487 in the diet was 16.1% compared to 53.5% in control rabbits. CAY10487 also exhibits antioxidant activity, inhibiting copper-mediated oxidation of low-density lipoprotein by about 75% at a concentration of 2 μM.
市场产品/服务共显示1个结果
  • 供应商
    TargetMolSC
    规格
    货期
    35日内发货
    纯度
    -
    ¥ 720.00
    1

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