Name: Nebentan
Rating: 5 (10 reviews)

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HIT ID:HIT214320912
Cas No:403604-85-3
常用名:Nebentan
IUPAC:(1E)-N-[6-methoxy-5-(2-methoxyphenoxy)-[2,2'-bipyrimidin]-4-yl]-2-phenylethene-1-sulfonamide
IUPAC:(1E)-N-[6-methoxy-5-(2-methoxyphenoxy)-[2,2'-bipyrimidin]-4-yl]-2-phenylethene-1-sulfonamide
InChI key:LONWRQOYFPYMQD-DTQAZKPQSA-N

分子式:C24H21N5O5S
分子量:491.52
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:COc1ccccc1Oc1c(NS(=O)(=O)\C=C\c2ccccc2)nc(nc1OC)-c1ncccn1
SMILES:COc1ccccc1Oc1c(NS(=O)(=O)\C=C\c2ccccc2)nc(nc1OC)-c1ncccn1

Nebentan (YM598) is a potent, selective and orally active non-peptide endothelin ETA receptor antagonist through the modification of Bosentan . Nebentan inhibits [125I] endothelin-1 binding to cloned human endothelin ETA and ETB receptor, with Ki of 0.697 nM and 569 nM, respectively[1]. YM598 can ameliorate the progression of cor pulmonale and myocardial infarction in vivo[2].

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