Name: p38α inhibitor 2
Rating: 5 (10 reviews)

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HIT ID:HIT214320916
Cas No:1095003-80-7
常用名:p38α inhibitor 2
IUPAC:N-cyclopropyl-4-methyl-3-{3-[(2-{2-[2-(methylamino)ethoxy]phenyl}propan-2-yl)amino]-2-oxo-1,2-dihydropyrazin-1-yl}benzamide
IUPAC:N-cyclopropyl-4-methyl-3-{3-[(2-{2-[2-(methylamino)ethoxy]phenyl}propan-2-yl)amino]-2-oxo-1,2-dihydropyrazin-1-yl}benzamide
InChI key:SAZVRXTVWZAHBI-UHFFFAOYSA-N

分子式:C27H33N5O3
分子量:475.593
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:CNCCOc1ccccc1C(C)(C)Nc1nccn(-c2cc(ccc2C)C(=O)NC2CC2)c1=O
SMILES:CNCCOc1ccccc1C(C)(C)Nc1nccn(-c2cc(ccc2C)C(=O)NC2CC2)c1=O

p38α inhibitor 2 is a highly potent and selective p38α MAPK inhibitor, with a pIC50 of 9.6. p38α inhibitor 2 inhibits the hERG ion channel (IC50=27 μM) and shows a promising selectivity profile when tested in a panel of 51 other protein kinases (<30% inhibition at 10 μM concentration) and a panel of 141 other biological targets[1].

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