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- HIT ID:HIT214320937
- Cas No:28872-28-8
- 常用名:Jacaric Acid
- InChI key:DQGMPXYVZZCNDQ-KDQYYBQISA-N
- 分子式:C18H30O2
- 分子量:278.436
- 氢键供体数 (HBD):
- 氢键受体数 (HBA):
- LogP:
- Jacaric acid is a conjugated polyunsaturated fatty acid first isolated from seeds of Jacaranda plants. Structurally, it is an 18-carbon ω-6 triene isomer of γ-linolenic acid . Jacaric acid induces cell cycle arrest and apoptosis in a variety of cancer cell lines (GI50 = 1-5 μM). It increases the production of reactive oxygen species, and cytotoxicity is abolished by the antioxidant α-tocopherol, suggesting that apoptosis results from oxidative stress. Jacaric acid is metabolized in vivo to conjugated linoleic acid , which is also cytotoxic to cancer cells. Jacaric acid inhibits cyclooxygenase-1 in vitro (Ki = 1.7 μM) and, with long term feeding, decreases stearoyl-CoA desaturase expression and activity in mice.
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