Name: Dichlorphenamide-13C6
Rating: 5 (10 reviews)

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HIT ID:HIT214320949
Cas No:1391054-76-4
常用名:Dichlorphenamide-13C6
别名:Dichlorphenamide-13C6
IUPAC:4,5-dichloro(1,2,3,4,5,6-13C6)benzene-1,3-disulfonamide
IUPAC:4,5-dichloro(1,2,3,4,5,6-13C6)benzene-1,3-disulfonamide
InChI key:GJQPMPFPNINLKP-IDEBNGHGSA-N

分子式:C6H6Cl2N2O4S2
分子量:311.1
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:NS(=O)(=O)[13c]1[13cH][13c](Cl)[13c](Cl)[13c]([13cH]1)S(N)(=O)=O
SMILES:NS(=O)(=O)[13c]1[13cH][13c](Cl)[13c](Cl)[13c]([13cH]1)S(N)(=O)=O

Dichlorphenamide-13C6is intended for use as an internal standard for the quantification of dichlorphenamide by GC- or LC-MS. Dichlorphenamide is a sulfonamide and an orally bioavailable carbonic anhydrase (CA) inhibitor (Kis = 1.20, 38, 50, and 50 nM for the human CA isoforms CAI, CAII, CAIX, and CAXII, respectively).1It lowers intraocular pressure in rabbits when 50 μl of a 10% solution is applied topically to the eye.2Dichlorphenamide rescues the potassium deficiency and prevents insulin-induced paralysis in a rat model of familial hypokalemic periodic paralysis when administered at a dose of 5.6 mg/kg per day for ten days.3Formulations containing dichlorphenamide have been used in the treatment of glaucoma and primary periodic paralysis.

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