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HIT214320958
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HIT214320958
  • HIT ID:HIT214320958
  • Cas No:147349-28-8
  • 常用名:S-NEPC
  • IUPAC:4-nitrophenyl [(2S,3S)-3-phenyloxiran-2-yl]methyl carbonate
    IUPAC:4-nitrophenyl [(2S,3S)-3-phenyloxiran-2-yl]methyl carbonate
  • InChI key:NIEXHSMFFPOGRX-GJZGRUSLSA-N
  • 分子式:C16H13NO6
  • 分子量:315.281
  • 氢键供体数 (HBD):
  • 氢键受体数 (HBA):
  • LogP:
  • SMILES:O=C(OC[C@@H]1O[C@H]1c1ccccc1)Oc1ccc(cc1)N(=O)=O
    SMILES:O=C(OC[C@@H]1O[C@H]1c1ccccc1)Oc1ccc(cc1)N(=O)=O
  • Cytochrome P450 metabolites of arachidonic acid, such as 11(12)-EpETrE and 14(15)-EpETrE have been identified as endothelium derived hyperpolarizing factors with vasodilator activity. Soluble epoxide hydrolase (sEH) catalyzes the conversion of EpETrEs to the corresponding DiHETrEs thereby diminishing their activity. Inhibitors of sEH may therefore have clinical utility for treating hypertension and systemic inflammation. S-NEPC is a colorimetric substrate used to measure sEH activity. It also is a substrate for Glutathione S-transferase, microsomal epoxide hydrolase and porcine liver carboxylesterase. Hydrolysis of S-NEPC by sEH yields 4-nitrophenol which can be quantified spectrophotometrically at 405 nm. S-NEPC is adaptable for use in 96-well microwell plate readers.
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  • 供应商
    TargetMolSC
    规格
    货期
    35日内发货
    纯度
    -
    ¥ 497.00
    1

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