YW3-56 (hydrochloride) (technical grade) | YW3-56 (hydrochloride) (technical grade) | CAS 2309756-20-3 | AnyMole

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HIT214320973

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HIT214320973

HIT ID:HIT214320973
Cas No:2309756-20-3
常用名:YW3-56 (hydrochloride) (technical grade)
常用名:YW3-56 (hydrochloride) (technical grade)
别名:YW3-56 (hydrochloride) (technical grade)
别名:YW3-56 (hydrochloride) (technical grade)
IUPAC:(2S)-N-benzyl-5-(2-chloroethanimidamido)-2-{[6-(dimethylamino)naphthalen-2-yl]formamido}pentanamide hydrochloride
IUPAC:(2S)-N-benzyl-5-(2-chloroethanimidamido)-2-{[6-(dimethylamino)naphthalen-2-yl]formamido}pentanamide hydrochloride
InChI key:DBGNVJZDXMWWQR-JIDHJSLPSA-N

分子式:C27H33Cl2N5O2
分子量:530.49
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:Cl.CN(C)c1ccc2cc(ccc2c1)C(=O)N[C@@H](CCCNC(=N)CCl)C(=O)NCc1ccccc1
SMILES:Cl.CN(C)c1ccc2cc(ccc2c1)C(=O)N[C@@H](CCCNC(=N)CCl)C(=O)NCc1ccccc1

YW3-56 is an inhibitor of protein arginine deiminase 2 (PAD2) and PAD4 (IC50s = 0.5-1 and 1-5 μM, respectively).1It inhibits the growth of U2OS osteosarcoma cells (IC50= ~2.5 μM) in a p53-dependent mannerviainduction of SESN2 and subsequent inhibition of mTORC1. YW3-56 (10 mg/kg) reduces tumor growth in an S-180 murine sarcoma tumor model. It also inhibits tumor growth in the 1883 MDA-MB-231 breast cancer bone metastasis mouse xenograft model.2

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TargetMolSC
规格
货期
10-14周
纯度
-
¥ 17,200.00
1

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