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- HIT ID:HIT214320987
- Cas No:1306684-90-1
- 常用名:BMP-22
- InChI key:XWVBRTAQHMKHCE-UHFFFAOYSA-N
- 分子式:C22H39O3P
- 分子量:382.525
- 氢键供体数 (HBD):
- 氢键受体数 (HBA):
- LogP:
- BMP-22 is an inhibitor of autotaxin (IC50 = 170 nM). It is selective for autotaxin over the phosphodiesterases NPP6 and NPP7 at 10 μM. BMP-22 (0.1-1,000 nM) inhibits autotaxin-mediated production of lysophosphatidic acid (LPA) from lysophosphatidylcholine in vitro in a concentration-dependent manner. It inhibits LPC-dependent MM1 cell invasion of a human umbilical vein endothelial cell (HUVEC) monolayer. BMP-22 (0.5 mg/kg per day) decreases the number of lung metastatic foci in a B16/F10 syngeneic mouse melanoma model of lung metastasis.
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