Name: BMS-795311
Rating: 5 (10 reviews)

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HIT ID:HIT214320988
Cas No:939390-99-5
常用名:BMS-795311
IUPAC:N-[(1R)-1-(3-cyclopropoxy-4-fluorophenyl)-1-[3-fluoro-5-(1,1,2,2-tetrafluoroethoxy)phenyl]-2-phenylethyl]-4-fluoro-3-(trifluoromethyl)benzamide
IUPAC:N-[(1R)-1-(3-cyclopropoxy-4-fluorophenyl)-1-[3-fluoro-5-(1,1,2,2-tetrafluoroethoxy)phenyl]-2-phenylethyl]-4-fluoro-3-(trifluoromethyl)benzamide
InChI key:UBJMOTPQBCKENW-WJOKGBTCSA-N

分子式:C33H23F10NO3
分子量:671.535
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:FC(F)C(F)(F)Oc1cc(F)cc(c1)[C@](Cc1ccccc1)(NC(=O)c1ccc(F)c(c1)C(F)(F)F)c1ccc(F)c(OC2CC2)c1
SMILES:FC(F)C(F)(F)Oc1cc(F)cc(c1)[C@](Cc1ccccc1)(NC(=O)c1ccc(F)c(c1)C(F)(F)F)c1ccc(F)c(OC2CC2)c1

Potent cholesteryl ester transfer protein (CETP) inhibitor (IC50 = 4 nM in an enzyme-based scintillation proximity assay). Inhibits cholesteryl ester transfer and increases HDL-C levels in vivo. Orally bioavailable.

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