Name: 8-iso-15-keto Prostaglandin F2β
Rating: 5 (10 reviews)

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HIT ID:HIT214321003
Cas No:1621482-36-7
常用名:8-iso-15-keto Prostaglandin F2β
别名:8-iso-15-keto Prostaglandin F2β
IUPAC:(5Z)-7-[(1S,2R,3R,5R)-3,5-dihydroxy-2-[(1E)-3-oxooct-1-en-1-yl]cyclopentyl]hept-5-enoic acid
IUPAC:(5Z)-7-[(1S,2R,3R,5R)-3,5-dihydroxy-2-[(1E)-3-oxooct-1-en-1-yl]cyclopentyl]hept-5-enoic acid
InChI key:LOLJEILMPWPILA-WZDCOHRSSA-N

分子式:C20H32O5
分子量:352.471
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:CCCCCC(=O)\C=C\[C@H]1[C@H](O)C[C@@H](O)[C@H]1C\C=C/CCCC(O)=O
SMILES:CCCCCC(=O)\C=C\[C@H]1[C@H](O)C[C@@H](O)[C@H]1C\C=C/CCCC(O)=O

8-iso Prostaglandin F2β (8-iso PGF2β) is an isomer of PGF2α of non-enzymatic origin. It is one of 64 possible isomers of PGF2α which can be produced by free radical peroxidation of arachidonic acid. 8-iso PGF2β exhibits very weak contraction of human umbilical vein artery and does not promote aggregation of human whole blood. However, 8-iso PGF2β moderately contracts both the canine and porcine pulmonary vein, although the effect is much weaker than that exhibited by other isoprostanes such as 8-iso PGE1, 8-iso PGE2, or 8-iso PGF2α. 8-iso-15-keto PGF2β is a potential metabolite of 8-iso PGF2β via the 15-hydroxy PG dehydrogenase pathway. There are no published reports on the formation or biological activity of 8-iso-15-keto PGF2β.

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