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  3. HIT214321017
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HIT214321017
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HIT214321017
  • HIT ID:HIT214321017
  • Cas No:2375613-31-1
  • 常用名:CAY10744
  • IUPAC:2-(2-chlorophenyl)-4-(4-hydroxyphenyl)-5H-indeno[1,2-b]pyridin-6-ol
    IUPAC:2-(2-chlorophenyl)-4-(4-hydroxyphenyl)-5H-indeno[1,2-b]pyridin-6-ol
  • InChI key:FEGFONFVHVRWGK-UHFFFAOYSA-N
  • 分子式:C24H16ClNO2
  • 分子量:385.85
  • 氢键供体数 (HBD):
  • 氢键受体数 (HBA):
  • LogP:
  • SMILES:Oc1ccc(cc1)-c1cc(nc-2c1Cc1c-2cccc1O)-c1ccccc1Cl
    SMILES:Oc1ccc(cc1)-c1cc(nc-2c1Cc1c-2cccc1O)-c1ccccc1Cl
  • CAY10744 is a topoisomerase II-α poison.1 It inhibits topoisomerase II-α by 78.9% when used at a concentration of 20 μM. CAY10744 is selective for topoisomerase II-α over topoisomerase I providing 100 and 0% inhibition, respectively, at 100 μM. It inhibits proliferation of HCT15 colon, T47D breast, DU145 prostate, and HeLa cervical cancer cells (IC50s = 0.014, 0.00267, 0.072, and 2.46 μM, respectively). CAY10744 induces apoptosis in T47D cells when used at concentrations of 10 and 30 μM. CAY10744 (12 mg/kg per day) reduces tumor growth in an MDA-MB-231 orthotopic mouse model of breast cancer.
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  • 供应商
    TargetMolSC
    规格
    货期
    35日内发货
    纯度
    -
    ¥ 1,430.00
    1

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